The mitochondrial permeability transition

ZI Szabò - Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes

The ATP synthase--a splendid molecular machine.

An X-ray structure of the F1 portion of the mitochondrial ATP synthase shows asymmetry and differences in nucleotide binding of the catalytic beta subunits...

Boyer，D Paul - 《Annual Review of Biochemistry》

Oxidative Stress, Thiol Reagents, and Membrane Potential Modulate the Mitochondrial Permeability Transition by Affecting Nucleotide Binding to the Adenine ...

Stimulation of the mitochondrial permeability transition (MPT) in de-energized mitochondria by phenylarsine oxide (PheArs) is greater than that by diamide ...

AP Halestrap，KY Woodfield，CP Connern - 《Journal of Biological Chemistry》

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptoticBCL-2

The BCL-2 family of proteins is composed of both pro- and antiapoptotic regulators, although its most critical biochemical functions remain uncertain. The ...

PH Schlesinger，A Gross，Yin, X.-M.，... - 《Proc Natl Acad Sci U S A》

The Mitochondrial F0F1-ATPase proton pump is required for function of the proapoptotic protein Bax in yeast and mammalian cells.

The proapoptotic mammalian protein Bax associates with mitochondrial membranes and confers a lethal phenotype when expressed in yeast. By generating Bax-re...

S Matsuyama，Q Xu，J Velours，... - 《Molecular Cell》

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2

The BCL-2 family of proteins is composed of both pro- and antiapoptotic regulators, although its most critical biochemical functions remain uncertain. The ...

PH Schlesinger，A Gross，XM Yin，... - 《Proceedings of the National Academy of Sciences of the United States of America》

Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton鈥塮lux

We and others have recently shown that loss of the mitochondrial membrane potential (螖蠄) precedes apoptosis and chemical-hypoxia-induced necrosis and is prevented by Bcl-2. In this report, we examine the biochemical mechanism used by B...

S Shimizu，Y Eguchi，W Kamiike，... - 《Proceedings of the National Academy of Sciences of the United States of America》

Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle...

Reports that nuclear events typical of apoptosis can be reproduced by Xenopus egg extracts. Initial normality of nuclear assembly and protein import; Proce...

Newmeyer，Donald，D.，... - 《Cell》

Bernardi P & Petronilli V.The permeability transition pore as a mitochondrial calcium release channel: a critical appraisal. J Bioener Biomem 28: 131−137

Mitochondria from a variety of sources possess an inner membrane channel, the permeability transition pore. The pore is a voltage-dependent channel, activa...

P Bernardi，V Petronilli - 《Journal of Bioenergetics》

Release of cytochrome c from liver mitochondria during permeability transition.

The mitochondrial permeability transition (PT) follows opening of megachannels in the inner membrane and may be part of a programmed death pathway. Recentl...

SP Kantrow，CA Piantadosi - 《Biochem Biophys Res Commun》