摘要：

The present disclosure relates to polynucleotides encoding linked IL-12 polypeptides that include an interleukin-12 (IL-12) polypeptide and a membrane domain. The disclosure also includes a vector comprising the polynucleotide, a host cell comprising the polynucleotide or the vector, a polypeptide encoded by the polynucleotide, a composition comprising the polynucleotide, the vector, the host cell or polypeptide and a delivery agent, and cancer. Their use, including the treatment of

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