A novel family of growth factor receptors: a common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and the p75 IL-2 receptor beta-chain.
摘要：
Lymphokine and hematopoietic growth factors control the differentiation and proliferation of diverse cell types by binding to specific cell-surface receptors. Strikingly, the recently elucidated sequences of the interleukin-6 and erythropoietin receptors, and the interleukin-2 receptor β-chain (p75), display a significant evolutionary resemblance of their extracellular domains. This homology extends to the binding domains of the growth hormone/prolactin class of receptors. Alternatively, little similarity exists between the cytoplasmic extensions of these diverse receptors. I discuss the evolutionary and functional implications of this broad, mosaic receptor relationship, with particular reference to possible structural resemblances between the cognate growth factors.
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关键词：
Interleukin-6 receptor IL6R IL6R erythropoietin receptor EPOR EPOR growth hormone receptor GRHR GRHR prolacin receptor PRLR PRLR interleukin-2 receptor β-chain IL2Rβ IL2Rβ
DOI：
10.1016/0006-291X(89)91528-3
被引量：
年份：
1989
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