Multiple essential functions of neuregulin in development
摘要：
NEUREGULIN (also called NDF, heregulin, GGF and ARIA) is a member of the EGF family which induces growth and differentiation of epithelial, glial and muscle cells in culture. The biological effects of the factor are mediated by tyrosine kinase receptors. Neuregulin can bind directly to erbB3 and erbB4 and receptor heterodimerization allows neuregulin-dependent activation of erbB2 (refs 1, 2, 5). A targeted mutation in mice reveals multiple essential roles of neuregulin in development. Here we show that neuregulin -/ - embryos die during embryogenesis and display heart malformations. In addition, Schwann cell precursors and cranial ganglia fail to develop normally. The phenotype demonstrates thatneuregulin acts locally and frequently in a paracrine manner. All cell types affected by the mutation express either erbB3 or erbB4, indicating that either of these tyrosine kinase receptors can be a component in recognition and transmission of essential neuregulin signals.
展开
DOI：
10.1038/378753a0
被引量：
BMJ
Nature
Nature
(全网免费下载)
Springer
EBSCO
查看更多
掌桥科研
Semantic Scholar
万方医学
dx.doi.org
Cell Press
NCBI
Europe PMC
NCBI
Oxford Univ Press
AACR
JBC
adsabs.harvard.edu
ResearchGate
ProQuest
EBSCO
EBSCO
ajplung.physiology.org
jcb.rupress.org
science-open.com
genesdev.cshlp.org
mysciencework.com
pnas.org
iovs.org
mendeley.com
emboj.embopress.org
onAcademic
clinsci.org
readcube.com
bioscirep.org
SAGE
onlinecjc.ca
edoc.mdc-berlin.de
scienceopen.com
circres.ahajournals.org
biolreprod.org
molbiolcell.org
theoncologist.alphamedpress.org
stm.sciencemag.org
mcb.asm.org
cghjournal.org
genetics.org
jcs.biologists.org
dx.crossref.org
Nature
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
