An Analysis of Human MicroRNA and Disease Associations
摘要：
It has been reported that increasingly microRNAs are associated with diseases. However, the patterns among the microRNA-disease associations remain largely unclear. In this study, in order to dissect the patterns of microRNA-disease associations, we performed a comprehensive analysis to the human microRNA-disease association data, which is manually collected from publications. We built a human microRNA associated disease network. Interestingly, microRNAs tend to show similar or different dysfunctional evidences for the similar or different disease clusters, respectively. A negative correlation between the tissue-specificity of a microRNA and the number of diseases it associated was uncovered. Furthermore, we observed an association between microRNA conservation and disease. Finally, we uncovered that microRNAs associated with the same disease tend to emerge as predefined microRNA groups. These findings can not only provide help in understanding the associations between microRNAs and human diseases but also suggest a new way to identify novel disease-associated microRNAs.
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关键词：
Humans Sepsis Respiratory Distress Syndrome, Adult Wounds and Injuries Multiple Organ Failure Injury Severity Score Incidence Interleukin-10 Survival Analysis Case-Control Studies
DOI：
10.1371/journal.pone.0003420
被引量：
年份：
2008
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掌桥科研
万方医学
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