摘要：

This review surveys the recent developments in organometal- lic-chemistry-based methods for the preparation of imidazo [1,2-b]pyridazines by cyclization as well as their functionaliza- tion by means of cross-coupling reactions such as Sonogashira, Heck, Negishi, Suzuki-Miyaura, Kumada and Stille. In addition, the advances made on the C-H activation of imidazo[1,2-b] pyridazines using C-arylation, C-benzylation and C-alkylation are also reviewed. Furthermore, the recent reports on the N- arylation of this heterocyclic system are discussed and high- lighted. The sequential couplings as well as the one-pot functionalization of two different positions on the imidazo[1,2- b]pyridazine systems are also reviewed. Procedures in which metal-based catalysis is not involved in the functionalization of imidazo[1,2-b]pyridazines are not included in this review.

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