摘要：

Figure 1--Effects of Mir155 knockout on atherosclerosis, obesity, and metabolism in Ldlr2/2 mice. Male Mir155+/+Ldlr2/2 and Mir1552/2Ldlr2/2 mice were fed a DDC for 24 weeks. A: Lesion and necrotic core areas in aortic roots in mice after the 24-week DDC feeding period (n = 10 mice/group). Scale bars: 100 mm. B: Cholesterol levels in VLDL, LDL, and HDL fractions from mice after the 24-week DDC feeding period analyzed by high-performance liquid chromatography (n = 8 mice/group). C: Body weight gain of mice during the 24-week DDC feeding period (n = 10 mice/group). D and E: Quantitation of eWAT weight (D) and adipocyte size in the eWAT (E) from mice after the 24-week DDC feeding period (n = 10 mice/group). Scale bars: 100 mm. F: Macrophage accumulation in eWAT from mice after the 24-week DDC feeding period assessed by Mac2 immunostaining (n = 9 mice/group). The nuclei were counterstained with DAPI. Scale bars: 50 mm. G: FBG concentrations in mice during the 24-week DDC feeding period (n = 10 mice/group). Data are represented as mean 6 SEM. *P , 0.05; **P , 0.01; ***P , 0.001.

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