摘要：

engineered fusion proteins that bind to and target nociceptive neurons, compositions comprising such engineered fusion proteins, and methods for treating pain using such engineered fusion proteins, or compositions containing engineered fusion proteins are disclosed herein. engineered fusion proteins contain domains derived from protein toxins such as anthrax toxin, the clostridial botulinum toxin family, disulfide-containing toxins and ab component type toxins.

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