摘要：

Background Anti‐ DNA /N‐methyl‐D‐aspartate receptor 2 ( NR 2) antibodies (anti‐ DNA / NR 2 antibodies) are a subset of anti‐ DNA autoantibodies that cross‐react with the extracellular domain of the GluN2A/GluN2B subunits of NR 2. These antibodies induce apoptosis of hippocampus neurons and psychiatric disorder in mice and humans. Neuropsychiatric system lupus erythematosus ( NPSLE ) can develop after initiation of corticosteroids (post‐steroid neuropsychiatric manifestation: PSNP ) or before treatment (de novo NPSLE ); however, pathophysiological differences between these subtypes remain unclear. The objective of this study was to clarify the prevalence of anti‐ DNA / NR 2 antibodies in patients with NPSLE . Methods This study involved a cohort of patients with NPSLE admitted to our hospital. NPSLE patients were classified into two groups, de novo NPSLE and PSNP ‐ SLE . Serum anti‐ DNA antibodies and anti‐ DNA / NR 2 antibodies were measured by enzyme‐linked immunosorbent assays. Results Serum samples were obtained from 24 patients with de novo NPSLE , 25 with PSNP ‐ SLE and 76 healthy controls ( HC ). The level of anti‐ DNA / NR 2 antibodies in patients with de novo NPSLE and PSNP ‐ SLE were also higher than those in HC . Positive correlation between anti‐ DNA antibodies and anti‐ DNA / NR 2 antibodies were found in PSNP ‐ SLE , but was not significant in de novo NPSLE . Conclusion The levels of anti‐ DNA / NR 2 antibodies in PSNP ‐ SLE were similar to those in de novo NPSLE . Anti‐ DNA / NR 2 antibodies in PSNP ‐ SLE were suggested as a dominant subset of anti‐ DNA antibodies, indicating that anti‐ DNA / NR 2 antibodies may be a predictive factor in PSNP ‐ SLE .

展开