摘要：

Prevention of surgical local infections at an early stage of implantation is greatly required for the success of implants in dentistry and orthopedics. A unique method to prevent bacterial infections is the local employment of antibacterial agents. Therefore, a great focusing on antimicrobial peptide (AMP) coatings on implant was directed to this project. The aim of this study is to evaluate the antibacterial effectiveness of Niobium oxide (Nb2O5) \polyethylene glycol (PEG 3500) biocomposite coating after immersion in the antimicrobial peptide (glycol peptide vancomycin) against bacteria involved in surgical infections of the dental implant (S.aureus and E.coli).Nb2O5\ PEG biocomposite coating was deposited on the surfaces of CPTi discs, using an RF magnetron sputtering method. Surface roughness was assessed using atomic force microscope. Antibacterial activity against S.aureus and E.coli was assessed in vitro using minimum inhibitory concentration (MIC) and agar disc diffusion tests. RF magnetron sputtering produced rough biocompatible coatings on titanium substrate. The collected data were analyzed with ANOVA test (p< 0.05). Biocomposite coating after immersion in the antimicrobial peptide (glycopeptide: vancomycin) reduced the growth of all examined bacterial in comparison to the unimmersed samples ( control sample) after three incubation intervals (24,48and 72h) . AMP was effective against the bacterial pathogens tested (S.aureus and E.coli ) at (2% and 6%) concentrations.

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