Two rearranged immunoglobulin kappa light chain genes in one mouse myeloma
摘要：
The organization of immunoglobulin gene segments coding for kappa light chains has been studied in uncloned and cloned DNA from mouse liver and a mouse myeloma. It is known that the C (constant, ref. 2) gene segment is present in the tumor DNA on two EcoRI fragments of 14 and 20 kb and in liver DNA on a 15 kb fragment. The 14 kb myeloma and the 15 kb liver fragment have been cloned previously. Here we report on the cloning of the 20 kb myeloma fragment and present detailed restriction maps covering about 22 kb of DNA surrounding the C gene segment in liver and tumor DNA. The region on the 20 kb fragment has been localized where a DNA rearrangement had occurred. The presence of two rearranged kappa light chain genes in one tumor is discussed in regard to the molecular basis of allelic exclusion.
展开
DOI：
10.1093/nar/8.8.1693
被引量：
年份：
1980
国家科技图书文献中心
(权威机构)
academic.oup.com
掌桥科研
Semantic Scholar
万方医学
查看更多
dx.doi.org
NCBI
(全网免费下载)
Europe PMC
(全网免费下载)
Oxford Univ Press
(全网免费下载)
Europe PMC
NCBI
NCBI
Oxford Univ Press
ResearchGate
ProQuest
Citeseer
(全网免费下载)
core.ac.uk
mysciencework.com
biomedsearch.com
(全网免费下载)
core.kmi.open.ac.uk
onacademic.com
deepdyve.com
Oxford University Press (OUP)
(全网免费下载)
NCBI
(全网免费下载)
Europe PMC
(全网免费下载)
Oxford Univ Press
(全网免费下载)
Citeseer
(全网免费下载)
biomedsearch.com
(全网免费下载)
Oxford University Press (OUP)
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
