The Role of the Sigma Factor sigmas (KatF) in Bacterial Global Regulation
摘要：
The encoded by (also known as , , csi-2, abrD, and in various alleles) has been biochemically confirmed to be an alternate sigma transcription factor and renamed . Its is controlled transcriptionally and posttranscriptionally by as yet undefined mechanisms that are active well into stationary phase. controls a regulon of 30 or more genes expressed in and during the transition to stationary phase. in the regulon, many of which have not been characterized, enhance long-term survival in nutrient-deficient medium and have a diverse group of functions including protection against DNA damage, the determination of morphological changes, the mediation of virulence, osmoprotection, and thermotolerance. Differential expression of subfamilies of genes within the regulon is effected by supplementary regulatory factors, working both individually and in combination to modulate activity of different -dependent promoters.
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DOI：
10.1146/annurev.micro.48.1.53
被引量：
年份：
1994
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