摘要：

The present invention relates to the drugs for containing poorly water-soluble in preparation of small particle to include the following steps:(One)The poorly water-soluble of high shear mixing object drug and a kind of or more than one surface reactive material aqueous carrier in the first temperature range there is no organic solvent or the poorly water-soluble higher than fusing point drug,To form the hot suspension containing drug,Then(Step b)Sum of the suspension being heated described in homogenizing within the scope of first pressure is after first temperature range is to form the heated homogenate containing drug,(Three)The drug of the following poorly water-soluble of melting temperature within the scope of the cooling heated homogenate to second temperature forms briefly stable type cooled homogenate and contains drug,Then(Step d)Apply particle and stablizes the second pressure range for being lower than drug melting point within the scope of high power treatment to the cooled homogenate second temperature,Contain drug to form the little particle of cooling stably dispersing,Then(It is multiple)Optionally dry cooling dispersion is to form the drug that dry little particle contains poorly water-soluble.

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