摘要：

A case of bilateral primary malignant lymphoma of the breast in a 30 year old woman is described. The tumors were first discovered during a self-examination of the breast at the 7th month of pregnancy. Thereafter they rapidly increased in size. The patient underwent simple bilateral mastectomy, and histological examination revealed a centroblastic/centro-cytic lymphoma. The patient is alive and well 9 months after mastectomy.Gli autori descrivono un caso di linfoma non-Hodgkin insorto primitivamente nelle mammelle di una donna di 30 anni. Evidenziate durante un autoesame del seno al settimo mese di gravidanza, Ie neoplasie mostrarono una crescita rapida. La paziente, sottoposta a mastectomia semplice bilaterale con diagnosi istopatologica di linfoma centroblastico/cen-trocitico, è in buone condizioni generali a 9 mesi dall'intervento.ReferencesSection:1. André, J.M., Contesso, G., Caillou, B., Lacombe, M.J., Spielmann, M.: Lymphomes malins et autre hématosarcomes à localisation mammaire initiale. Bull. Cancer (Paris), 70: 401–409, 1983. Google Scholar, Medline2. Bucciarelli, E.: Alcuni aspetti biometrici del cancro della mammella nel materiale bioptico della Sezione Istopatologica del Consorzio Provinciale per la Diagnosi e la Cura dei Tumori (C.P.D.C.T.) in Perugia. Lav. Anat. Patol. Perugia, 24: 57–63, 1964. Google Scholar3. Brustein, S., Kimmel, M., Lieberman, P.H., Filippa, D.A., Rosen, P.P.: Malignant lymphoma of the breast. A study of 53 patients. Ann. Surg., 205: 144–150, 1987. Google Scholar, Crossref, Medline4. Freeman, C., Berg, J.W., Cutler, S.J.: Occurrence and prognosis of extranodal lymphomas. Cancer, 29: 252–260, 1972. Google Scholar, Crossref, Medline5. Gout, P.W., Beer, C.T., Noble, R.L.: Prolactin-stimu-lated growth of cell cultures established from malignant Nb rat lymphomas. Cancer Res., 40: 2433–2436, 1980. Google Scholar, Medline6. Lennert, K., Mohri, N., Stein, H., Kaiserling, E.: The histopathology of malignant lymphoma. Br. J. Haematol., 31: 193–203 (Suppl.), 1975. Google Scholar, Crossref, Medline7. Mambo, N.C., Burke, J.S., Butler, J.J.: Primary malignant lymphomas of the breast. Cancer, 39: 2033–2040, 1977. Google Scholar, Crossref, Medline8. Rappaport, H.: Tumors of the hematopoietic system. In: Atlas of Tumor Pathology. Section 3, fascicle 8. A.F.I.P., Washington DC, 1966. Google Scholar9. Robbins, G.F., Berg, J.W.: Bilateral primary breast cancers. A prospective clinicopathological study. Cancer, 17: 1501–1527, 1964. Google Scholar, Crossref, Medline10. Schouten, J.T., Weese, J.L., Carbone, P.P.: Lymphoma of the breast. Ann. Surg., 194: 749–753, 1981. Google Scholar, Crossref, Medline11. Shepherd, J.J., Wright, D.H.: Burkitt's tumour presenting as bilateral swelling of the breast in women of child-bearing age. Br. J. Surg., 54: 776–780, 1967. Google Scholar, Crossref, Medline12. Smith, M.R., Brustein, S., Straus, D.J.: Localized non-Hodgkin's lymphoma of the breast. Cancer, 59: 351–354, 1987. Google Scholar, Crossref, Medline13. Sternberger, L.A.: Immunocytochemistry. 2nd ed., J. Wiley and Sons, New York, 1979. Google Scholar14. Tateno, M., Yoshiki, T., Itoh, T., Takamuro, M., Saito, C.: A case of primary B-cell lymphoma of the breast. Light and electron microscopy, and immunologic cell markers. Cancer, 52: 671–674, 1983. Google Scholar, Crossref, Medline15. Taylor, C.R.: Immunoperoxidase techniques. Arch. Pathol. Lab. Med., 102: 113–121, 1979. Google Scholar16. Warnke, R., Levy, A.: Detection of T and B cell antigens with hybridoma monoclonal antibodies: a biotin-horseradish peroxidase method. J. Histo-chem. Cytochem., 28: 771–776, 1980. Google Scholar, SAGE Journals17. Wiseman, C., Liao, K.T.: Primary lymphoma of the breast. Cancer, 26: 94–99, 1972. Google Scholar

展开