摘要：

A highly-controllable core-shell silica-MIPs absorbent by anchoring a MIPs layer to the surface of SiO2 nanoparticles via a surface molecular imprinting process was prepared. The templates were covalently modified with function- al monomers to form precursor EstSi. The latter together with coupling rea- gent KH-570, were grafted onto the surface of SiO2 nanoparticles before po- lymerization, to ensure the quantity and quality of imprinted sites on the surface of the covalently attached matrix. The as-synthesized core-shell na- nomaterials (SiO2@MIP2) were then evaluated for selective adsorption of 17β-estradiol (E2) with Raman spectra as detection method. The results indi- cate that SiO2@MIP2 can fast and selectively adsorb E2 from structural ana- logues, with detection limit of 0.01 μmol/l.

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