Insect chemosterilants. 11. Substituted 3,5-diamino-1,2,4-dithiazolium salts and related compounds.

来自 ACS

阅读量:

32

作者:

JE OliverSC ChangRT BrownJB StokesAB Borkovec

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摘要:

1,2,4-Dithiazolium salts substituted in 3 and 5 positions with Me 2N, pyrrolidinyl, or morpholino groups were active as chemosterilants in the male house fly. When combined with one of these substituents, Et 2N, piperidino, and substituted pyrrolidinyl groups also gave active compounds. Several other 3,5-disubstituted 1,2,4-dithiazolium salts were inactive. Analogs of dithiazolium compounds containing 1,2-dithiolium, 1,2,4-dithiazole, 1,2,4-thiadiazole, 1,3,4-thiadiazole, 1,2,4-triazole, 1,3,4-oxadiazole, 1,2,5-oxadiazole, and 1,2,5-thiadiazole rings substituted with Me 2N or other groups did not yield active sterilants. Analogs of the chemosterilant 1,1,5,5-tetramethyl-2,4-dithiobiuret were also inactive except for the moderately effective 1-(dimethylthiocarbamoyl)-2,3,3-trimethyl-2-thiopseudourea.

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DOI:

10.1021/jm00273a025

被引量:

31

年份:

1972

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1973
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