Mucin 1, Thomsen-Friedenreich expression and galectin-1 binding in endometrioid adenocarcinoma: an immunohistochemical analysis.

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作者：

I Mylonas，D Mayr，H Walzel，N Shabani，K Friese

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摘要：

Background and Aim : Altered mucin 1 (MUC1) secretion patterns have been implicated in several cancerous conditions including gastric, colorectal and breast carcinomas. Additionally, an association between the expression of MUC1, Thomsen-Friedenreich (TF) antigen, and binding of gal-1 (gal1) has been proposed. Therefore, the aims of this study were to determine the frequency and tissue distribution of MUC1, TF and gal-1 binding in endometrioid adenocarcinomas. Materials and Methods: Endometrial carcinomas diagnosed with only one histological tumor form (endometrioid adenocarcinomas) were obtained from 70 patients and classified according to the WHO grading system (G1 =50; G2=12; G3=8). An immuno-histochemical analysis was performed with specific antibodies against MUC1 and TF and in addition with biotinylated gal-1, followed by a semiquantitative evaluation and statistical analysis (Χ

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关键词：

Humans Carcinoma, Endometrioid Endometrial Neoplasms Galectin 1 Tumor Markers, Biological Antigens, Tumor-Associated, Carbohydrate Immunohistochemistry Female Mucin-1