摘要：

Diastereomeric [(S)-l-benzylpyrrolidin-2-yl]-(R)-[(phenyl)-ethanamine]nd [(S)-l-benzylpyrrolidin-2-yl]-(S)-[(phenyl)methanamine], wereynthesizedyelective internalackside nucleophilicubstitutionfheorrespondingctivated phenylprolinols. X-Ray diffractiontructuresfrystallinecetamide derivativesonfirmedhenticipatedtereochemistryor_nibeactionechanism. Inrderopplyhiseactionoheynthesisfifunctionalnalogs,eriesfragmentsuchshioureaoietyndulfonamideunctions were introducedorheunctionalizationfhe primarymino group inheubstrate,btainingoretablend potentiallyseful derivatives.

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