Preparation of Heterocyclic Amines via a Copper(I)-Mediated Oxidative Cross-Coupling of Organozinc Reagents with Lithium Amides
摘要：
Functionalized heteroaromatic amines are readily prepared by the oxidative coupling of poly functional zinc amidocuprates using PhI(OAc)_2 as oxidant. Various sensitive heterocyclic organometallics undergo this oxidative cross-coupling reaction furnishing aminated heteroaromatics. A high functional group tolerance and relative insensibility to steric hindrance characterize this general amination reaction. A practical procedure for the preparation of protected primary and secondary as well as tertiary heteroaryl amines is described.
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DOI：
10.1055/S-0029-1220008
年份：
2010
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