In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

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14

摘要:

Emerging evidence suggests that an ampli- fiable protease cascade consisting of multiple aspartate- specific cysteine proteases (ASCPs) is responsible for the apoptotic changes observed in mammalian cells undergoing programmed cell death. Here we describe the cloning of two novel ASCPs from human Jurkat T-lymphocytes. Like other ASCPs, the new proteases, named Mch4 and Mch5, are derived from single chain proenzymes.

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DOI:

10.1073/PNAS.93.15.7464

年份:

1996

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