登录注册
高级搜索
包含全部检索词
包含精确检索词
包含至少一个检索词
不包含检索词
出现检索词的位置
文章任何位置
位于文章标题
作者
机构
出版物 期刊
会议
发表时间  - 
语言检索范围 不限
不限 英文 中文
文献
期刊
学者
论文查重 优惠
论文查重
开题分析
单篇购买
文献互助

Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach.

来自 万方

阅读量：

263

作者：

AD Rieux，V Fievez，M Garinot，YJ Schneider，V Préat

展开

摘要：

Peptides and proteins remain poorly bioavailable upon oral administration. One of the most promising strategies to improve their oral delivery relies on their association with colloidal carriers, e.g. polymeric nanoparticles, stable in gastrointestinal tract, protective for encapsulated substances and able to modulate physicochemical characteristics, drug release and biological behavior. The mechanisms of transport of these nanoparticles across intestinal mucosa are reviewed. In particular, the influence of size and surface properties on their non-specific uptake or their targeted uptake by enterocytes and/or M cells is discussed. Enhancement of their uptake by appropriate cells, i.e. M cells by (i) modeling surface properties to optimize access to and transport by M cells (ii) identifying surface markers specific to human M cell allowing targeting to M cells and nanoparticles transcytosis is illustrated. Encouraging results upon in vivo testing are reported but low bioavailability and lack of control on absorbed dose slow down products development. Vaccines are certainly the most promising applications for orally delivered nanoparticles.

展开

关键词：

Nanoparticles Oral delivery M cells Proteins Vaccines Biodegradable polymers

DOI：

10.1016/j.jconrel.2006.08.013

被引量：

1248

年份：

2006

收藏 引用 批量引用 分享
全部来源 免费下载 求助全文 全文购买

通过文献互助平台发起求助，成功后即可免费获取论文全文。

我们已与文献出版商建立了直接购买合作。

你可以通过身份认证进行实名认证，认证成功后本次下载的费用将由您所在的图书馆支付

您可以直接购买此文献，1~5分钟即可下载全文，部分资源由于网络原因可能需要更长时间，请您耐心等待哦~

身份认证 全文购买

相似文献

参考文献

引证文献

辅助模式

0

引用

文献可以批量引用啦~
欢迎点我试用！

引用