Synthesis of Cholesteryl Supports and Phosphoramidite for Automated DNA Synthesis of TripleHelix Forming Oligonucleotides (Tfos)
摘要：
DMT-Cholesteryl succinylamino solid supports (CPG, loading: 33 mole/gram and TentaGel loading: 152 mole/gram) and DMT-cholesteryl phosphoramidite were prepared for use in automated DNA synthesis of cholesteryl modified TFOs in the synthesis scales from 0.2 to 300 mole. The modified TFOs were found to have a 5 to 50 fold increase in their uptake properties.
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DOI：
10.1080/07328319308018556
被引量：
年份：
1993
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