Computational Proteome-Wide Study for the Prediction of Escherichia coli Protein Targeting in Host Cell Organelles and Their Implication in Development of Colon Cancer
摘要：
Enterohemorrhagic <named-content>Escherichia coli</named-content> infection is associated with gastrointestinaldisorders, includingdiarrhea and colorectal cancer. Although evidences have establishedthe involvement of <named-content>E. coli</named-content> in the growthof colon cancer, the molecular mechanisms of carcinogenesis of cancergrowth and development are not well understood. We analyzed <named-content>E. coli</named-content> protein targeting in host cell organellesand the implication in colon cancer using in silico approaches. Ourresults indicated that many <named-content>E. coli</named-content> proteins targeted the endoplasmic reticulum (ER), ER membranes,Golgi apparatus, Golgi apparatus membranes, peroxisomes, nucleus,nuclear membrane, mitochondria, and mitochondrial membrane of hostcells. These targeted proteins in ER, Golgi apparatus, peroxisomes,nucleus, and mitochondria may alter the normal functioning of variouspathways including DNA repair, apoptosis, replication, transcription,and protein folding in <named-content>E. coli</named-content>-infectedhost cells. The results of the current in silico study provide insightsinto <named-content>E. coli</named-content> pathogenesis and may aidin designing new preventive and therapeutic strategies.
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DOI：
10.1021/acsomega.9b04042
年份：
2020
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