The origin and function of the pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily.

来自 Semantic Scholar

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114

作者：

NM Sherwood，SL Krueckl，McRory John E.

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摘要：

The ()/ superfamily includes nine hormones in that are related by structure, distribution (especially the brain and gut), function (often by activation of cAMP), and receptors (a subset of seven-receptors). The nine hormones include , (), , (), GH-releasing hormone (), histidine-methionine (), , , and (VIP). The origin of the ancestral superfamily members is at least as old as the invertebrates; the most ancient and tightly conserved members are and . Evidence to date suggests the superfamily began with a gene or exon duplication and then continued to diverge with some gene duplications in . The function of is considered in detail because it is newly (1989) discovered; it is tightly conserved (96% over 700 million years); and it is probably the ancestral molecule. The diverse functions of include regulation of proliferation, differentiation, and in some cell populations. In addition, regulates metabolism and the cardiovascular, , and immune systems, although the physiological event(s) that coordinates responses remains to be identified.

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关键词：

Glucagon Multigene Family Neuropeptides Receptors, Cell Surface pituitary adenylate cyclase activating polypeptide 胰高血糖素多基因族神经肽类