In-parallel Ventilator Sharing During an Acute Shortage: Too Much Risk for a Wider Uptake

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11

作者:

JG ChaseYS ChiewB LambermontP MorimontT Desaive

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摘要:

1. Lambrecht BN, Hammad H. The immunology of asthma. Nat Immunol 2015;16:45–56. 2. Pavord ID, Korn S, Howarth P, Bleecker ER, Buhl R, Keene ON, et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 2012;380:651–659. 3. Bleecker ER, FitzGerald JM, Chanez P, Papi A, Weinstein SF, Barker P, et al.; SIROCCO Study Investigators. Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with highdosage inhaled corticosteroids and long-acting b2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial. Lancet 2016;388:2115–2127. 4. Nair P, Wenzel S, Rabe KF, Bourdin A, Lugogo NL, Kuna P, et al.; ZONDA Trial Investigators. Oral glucocorticoid-sparing effect of benralizumab in severe asthma. N Engl J Med 2017;376: 2448–2458. 5. Bel EH, Wenzel SE, Thompson PJ, Prazma CM, Keene ON, Yancey SW, et al.; SIRIUS Investigators. Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma. N Engl J Med 2014;371: 1189–1197. 6. Kolbeck R, Kozhich A, Koike M, Peng L, Andersson CK, Damschroder MM, et al. MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function. J Allergy Clin Immunol 2010;125:1344–1353, e2. 7. Wang B, Yan L, Yao Z, Roskos LK. Population pharmacokinetics and pharmacodynamics of benralizumab in healthy volunteers and patients with asthma. CPT Pharmacometrics Syst Pharmacol 2017;6: 249–257. 8. Smith DA, Minthorn EA, Beerahee M. Pharmacokinetics and pharmacodynamics of mepolizumab, an anti-interleukin-5 monoclonal antibody. Clin Pharmacokinet 2011;50:215–227. 9. Leckie MJ, ten Brinke A, Khan J, Diamant Z, O'Connor BJ, Walls CM, et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000;356:2144– 2148. 10. Ramakrishnan S, Camp JR, Vijayakumar B, Hardinge FM, Downs ML, Russell REK, et al. The use of benralizumab in the treatment of near-fatal asthma: a new approach. Am J Respir Crit Care Med 2020;201:1441–1443.

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关键词:

COVID-19 PATIENTS

DOI:

10.1164/rccm.202006-2420LE

年份:

2020

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