摘要：

Reports on the identification of a novel mitochondrial protein, Smac, which promotes caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway. Promoter of apoptosis; Maturation and regulation of Smac; Stimulation of caspase activation by Smac; Neutralization of inhibitor of apoptotic protein (IAP); Antagonist of mitochondria-derived IAP.

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