Involvement of an ICE-like protease in Fas-mediated apoptosis
摘要：
FAS is a type-I membrane protein that transduces an apoptotic signal 1,2 . Binding of Fas ligand or agonistic anti-Fas antibody to Fas kills the cells by apoptosis 3 . Studies in the nematode Caenorhabditis elegans have suggested that proteases such as interleukin-Iβ-converting enzyme (ICE) or the product of the C . elegans cell-death gene ced -3 are involved in apoptotic signal transduction 4 . The activity of ICE can be inhibited by the product of crmA, a cytokine-response modifier gene encoded by cowpox virus 5á€-7 . We report here that expression of crmA inhibits cytotoxicity induced by anti-Fas antibody or tumour necrosis factor (TNF). We have found a specific ICE inhibitor tetrapeptide (acetyl-Tyr-Val-Ala-Asp-chloromethylketone) 8,9 that also prevents apoptosis induced by anti-Fas antibody. These results suggest an involvement of an ICE-like protease in Fas-mediated apoptosis and TNF-induced cytotoxicity.
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DOI：
10.1038/375078a0
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年份：
1995
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