Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency

来自 EBSCO

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作者：

Xian-Cheng Jiang，S Qin，C Qiao，K Kawano，AR Tall

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摘要：

Increased secretion and levels of ApoB-containing lipoproteins (BLp) commonly occur in familial hyperlipidemia, obesity and diabetes. The plasma phospholipid-transfer protein (PLTP) is known to mediate transfer of phospholipids between BLp and HDL during their intravascular metabolism. To address a possible role of PLTP in dyslipidemia and atherogenesis, we bred mice deficient in the gene encoding PLTP (PLTP-deficient mice) using different hyperlipidemic mouse strains. In ApoB-transgenic and ApoE-deficient backgrounds, PLTP deficiency resulted in reduced production and levels of BLp and markedly decreased atherosclerosis. BLp secretion was diminished in hepatocytes from ApoB-transgenic PLTP-deficient mice, a defect that was corrected when PLTP was reintroduced in adenovirus. The studies reveal a major, unexpected role of PLTP in regulating the secretion of BLp and identify PLTP as a therapeutic target.

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关键词：

Apolipoproteins B Arteriosclerosis Lipid Metabolism, Inborn Errors 载脂蛋白B类动脉硬化脂质代谢缺陷, 先天性

DOI：

10.1038/89977

被引量：

556

年份：

2001