Quinoline derivatives, processes for their preparation, intermediates, and pharmaceutical compositions containing these derivatives

阅读量:

12

作者:

TH BrownCA LeachRJ IfeDJ Keeling

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摘要:

Compounds of structure (I): in which R<1> to R<4> are the same or different and are each hydrogen, C1-4alkyl, C1-6alkoxy, phenyl, C1-6alkylthio, C1-4alkanoyl, amino, C1-6alkylamino, diC1-6alkylamino, halogen, trifluoromethyl or nitro, provided that at least two of R<1> to R<4> are hydrogen. R<5> to R<9> are the same or different and are each hydrogen, C1-6alkyl, C1-6alkoxy, C1-6alkylthio, halogen, cyano, amino, hydroxy, carbamoyl, carboxy, C1-6alkanoyl, trifluoromethyl or nitro, provided that at least two of R<5> to R<9> are hydrogen; R<1><0> is hydrogen, C1-6alkyl, C1-6alkoxy, halogen, hydroxy, -CH2OH, C1-6alkylthio, NH(CH2)nOH in which n is 0 to 4 or a group -NR<1><1>R<1><2> in which R<1><1> and R<1><2> are the same or different and are each hydrogen or C1-6alkyl or together with the nitrogen atom to which they are attached form a saturated or unsaturated ring; and A is -N=N-; or -CH=N-; and pharmaceutically acceptable salts thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy as inhibitors of gastric acid secretion and bone resorption. ####google_ad_client = 'pub-1586334167197709'; google_ad_channel = '647+871+557+508'; google_feedback = 'on'; google_ad_width = 336; google_ad_height = 280; google_ad_format = "336x280_as"; google_ad_type = "text,html"; google_color_border = "FFFFFF"; google_color_bg = "transparent"; google_color_link = "FF6923"; google_color_url = "999999"; google_color_text = "666666";

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DOI:

EP0441036 A2

被引量:

10

年份:

1991

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1999
被引量:3

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