AN ORAL COMPOSITION CONTAINING PARTICLES COMPRISING AN ACTIVE SUBSTANCE
申请(专利)号:
AU19880015460
申请日期:
1988-03-11
公开/公告号:
AU1546088A
公开/公告日期:
1988-10-10
申请(专利权)人:
BENZON PHARMA A/S
被引量:
摘要:
An oral composition, which is intended to be dispersed in an aqueous carrier substantially immediately prior to administration contains a plurality of particles which comprise an active substance and which are combined with one or more adjuvants gelatinization or blowing agents capable of forming a viscous medium around the particles in an aqueous carrier, said particles being further provided with a masking surface layer when dispersed in the aqueous carrier. This surface serves to mask the presence of uneven surfaces on the particles and prevent the particles from adhering to the mucous membranes of the mouth upon ingestion of the composition, thus making easier the administration of large doses of an active substance . The masking surface layer preferably has a higher viscosity of the viscous medium in the immediate vicinity of the particles relative to the viscosity of the aqueous medium surrounding them. such a composition ready for use is prepared by mixing with an aqueous carrier substantially immediately prior to administration of the composition.
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