2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents
摘要：
Based on the antimalarial properties observed for 2-acetylpyridine 4-phenyl-3-thiosemicarbazone (1), an extensive series of related thiosemicarbazones was prepared and tested against Plasmodium berghei in mice. Screening results indicated that the presence of the 2-pyridylethylidene group was critical and that certain phenyl, benzyl, phenethyl, or cycloalkyl groups at N4 of the thiosemicarbazone moiety also contribute to antimalarial activity.
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关键词：
Animals Mice Malaria Pyridines Thiosemicarbazones Antimalarials Plasmodium berghei Structure-Activity Relationship
DOI：
10.1021/jm00193a020
被引量：
年份：
1979
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