Organocatalytic Enantioselective [2+4]-Annulation of γ-Substituted Allenoates with N-Acyldiazenes for Synthesis of Optically Active 1,3,4-Oxadiazines
摘要：
An enantioselective [2+4]-annulation of γ-substituted allenoates with N-acyldiazenes has been developed for the first time. In the presence of a L-proline-derived DMAP analogue, the annulation proceeded smoothly to afford a broad range of 1,3,4-oxadiazine de-rivatives in good to excellent yields with high stereoselectivities. Notably, the catalytic strategy not only achieves the organocatalytic stereoselective [2+4]-annulation of γ-substituted allenoates with N-acyldiazenes for the first time, but also enables the formation of chiral six-membered ring containing three heteroatoms in one step.
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DOI：
10.1039/D0OB02508A
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