Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
The present invention relates to compounds of Formula I or II, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A pr...
S Nakajima，Z Miao，S Ying，... - US
PROBES
The present invention relates to probes, methods and apparatus for the detection of the presence or absence of non-contiguous cis-located nucleic acid sequ...
M Bunce，I Crosby - US
Apparatus for containing, cultivating, and harvesting photosynthetic marine microorganisms within water
An apparatus contains photosynthetic marine microorganisms within water, to permit the marine microorganisms to be cultivated and harvested. A self-supporting buoyant frame of the apparatus is to be placed within the water. A mesh lining...
J Stephens，KW Dickinson，K Ogilvie - US
MicroRNA COMPOSITIONS IN THE TREATMENT OF VEGF-MEDIATED DISORDERS
The invention provides methods of treating diseases caused by the over-production of a VEGF polypeptide by administering miRNA or miRNA inhibitor compositions to decrease at least one activity of a VEGF polypeptide.
ELIAS, Jack, A.，S Takyar - US
Conclusion and Future Perspectives
The lasers developed in FAST-DOT are mainly targeted toward compact sources of ultra-short pulses. As such, they utilize semiconductor quantum dots (QDs) a...
EU Rafailov - John Wiley & Sons, Ltd
Reagent and process for the identification and counting of biological cells
The invention relates to a reagent and a process for the identification and counting of biological cells in a sample. This reagent comprises a cell lysing agent selected from at least one detergent in a concentration capable of specifica...
D Lefevre，S Veriac，H Champseix - US
Ultrasound enhanced growth of microorganisms
A method of increasing the rate of growth, useful product production, or protein expression of a microorganism includes the step of exposing the microorganism to ultrasound having a frequency greater than about 1 MHz.
J Chen，J Xing，WT Ang - EP
Gene delivery
The present invention relates to a method of delivery of a therapeutic agent to a target cell the method comprising targeting particles comprising the therapeutic agent to the cell using magnetic means to apply a magnetic force to said p...
J Dobson，CD Batich - US
RNAi modulation of APOB and uses thereof
The invention relates to compositions and methods for modulating the expression of apolipoprotein B, and more particularly to the downregulation of apolipoprotein B by chemically modified oligonucleotides.
J Soutschek，HP Vornlocher，P Hadwiger，... - US
Cytoskeletal active rho kinase inhibitor compounds, composition and use
The present invention is directed to synthetic cytoskeletal active compounds that are inhibitors of rho-associated protein kinase. The present invention is also directed to pharmaceutical compositions comprising such compounds and a phar...
JW Lampe，PS Watson，DJ Slade，... - US
