Somatic Hypermutation Introduces Insertions and Deletions into Immunoglobulin V Genes

and of 25 additional insertions or deletions collected from the literature, suggest that secondary structural elements in the DNA sequences capable of producin...

PC Wilson，OD Bouteiller，YJ Liu，... - 《Journal of Experimental Medicine》

Cutting edge: a cis-acting DNA element targets AID-mediated sequence diversification to the chicken Ig light chain gene locus.

Somatic hypermutation and gene conversion are two closely related processes that increase the diversity of the primary Ig repertoire. Both processes are in...

N Kothapalli，DD Norton，SD Fugmann - 《Journal of Immunology》

The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells

This lack of targeting by the Ig hypermutation mechanism must be due to the lack of regulatory DNA elements, since the primary sequences of the three ...

HM Shen，M Nancy，K Nayun，... - 《International Immunology》

The roles of antibody variable region hypermutation and selection in the development of the memory B-cell compartment

Summary: Somatic hypermutation and selection of immunoglobulin (Ig) variable (V)-region genes, working in concert, appear to be essential for memory B-cell...

Tim，Manser，Kathleen，... - 《Immunological Reviews》

Somatic hypermutation of immunoglobulin and non–immunoglobulin genes

Somatic hypermutation (SHM) of immunoglobulin (Ig) genes is a highly specific mechanism restricted to B lymphocytes during only a few cell generations. Data presented here suggest that transcription of the target genes is required, but n...

U Storb，HM Shen，N Michael，... - 《Philosophical Transactions of the Royal Society B Biological Sciences》

Insertion of 2 kb of bacteriophage DNA between an immunoglobulin promoter and leader exon stops somatic hypermutation in a κ transgene

Somatic hypermutation in rearranged immunoglobulin variable genes occurs in a 2 kb region of DNA that is delimited on the 5′ side by the promoter and on t...

David B. Winter and Nasreen Sattar and Jia-Jia Mai and Patricia J. Gearhart - 《Molecular Immunology》

Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells

Noncoding RNAs are exquisitely titrated by the cellular RNA surveillance machinery for regulating diverse biological processes. The RNA exosome, the predom...

B Laffleur，J Lim，W Zhang，... - 《Nature Genetics》