Coprophilous fungi: antibiotic discovery and functions in an underexplored arena of microbial defensive mutualism

阅读量:

67

作者:

GF BillsJB GloerZ An

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摘要:

Microbial antibiotics can mediate mutualisms and interorganism communications. Herbivorous animal dung offers opportunities for discovery of new antibiotics from microbial communities that compete for a nutrient-rich, ephemeral resource. Distinct lineages form a specialized community of coprophilous (dung-colonizing) fungi. Bacteria, protists, invertebrates, the mammalian digestive system, and other fungi can pose challenges to their fitness in the dung environment. The well-characterized diversity of dung fungi offers accessible systems for dissecting the function of antibiotics and for exploring fungal genomes for new antibiotics. Their potential for antibiotic discovery is evidenced by a high frequency of antifungal antibiotics and bioactive secondary metabolites from limited prior efforts and from mapping biosynthetic pathways in the genomes of the coprophilous fungi Podospora anserina and Sordaria macrospora.

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DOI:

10.1016/j.mib.2013.08.001

被引量:

49

年份:

2013

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