摘要：

Many organic chemists, myself included, will remember being told in early undergraduate years "in organic synthesis water is a contaminant". From the very beginning it was made clear to you that in order to become proficient in organic synthesis, the first step was knowing how to dry your glassware, reagents, and solvents. Extreme measures should always be taken to avoid even trace quantities of water in your reaction flask, unless of course water was used as a reactant. In undergraduate labs, water was always the usual suspect whenever a reaction gave an unexpected outcome; "My reaction did not work"? "Well, was your glassware properly dried?" With the paradigm being that water has an adverse effect on most organic reactions, it may require a significant mind leap to think of water as a versatile solvent for organic synthesis.

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