Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms.

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595

作者：

R Shibata，K Sato，DR Pimentel，Y Takemura，K Walsh

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摘要：

Objective To explore the antioxidation effect of hypertonic sodium chloride hydroxyethyl starch 40(HH40) on rat cerebral ischemia/reperfusion injury.Methods 24 male SD rats were randomly divided into sham group,model group,low dose HH40 group and high dose HH40 group.A rat cerebral ischemia/reperfusion injury was made through embolization of the middle cerebral artery,and HH40 was infused sublingually 50 minutes after ischemia.24 hours after reperfusion,the activities of SOD and GSH-Px,and the level of MDA in serum or ischemic brain tissue were measured.Results Compared with sham group,model group had decreased activities of SOD and GSH-Px,but had an increased level of MDA in cerebral tissue,meanwhile had a decreased activity of GSH-Px in serum.Compared with model group,HH40 groups had a significantly decrease of the level of MDA and an elevation of SOD activity in ischemic brain tissue,as well as,an enhancing activity of GSH-Px in serum.Conclusion HH40 can enhance the antioxidation effect on rat cerebral ischemia/reperfusion injury and the ability of oxygen free radical clearance.

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关键词：

Hypertonic Sodium Chloride Hydroxyethyl Starch 40(HH40 Ischemia/reperfusion Antioxidation

DOI：

10.1038/nm1295

被引量：

1227

年份：

2012