Mitochondria, calcium and cell death: A deadly triad in neurodegeneration
摘要：
Mitochondrial Ca2+ accumulation is a tightly controlled process, in turn regulating functions as diverse as aerobic metabolism and induction of cell death. The link between Ca2+ (dys)regulation, mitochondria and cellular derangement is particularly evident in neurodegenerative disorders, in which genetic models and environmental factors allowed to identify common traits in the pathogenic routes. We will here summarize: i) the current view of mechanisms and functions of mitochondrial Ca2+ homeostasis, ii) the basic principles of organelle Ca2+ transport, iii) the role of Ca2+ in neuronal cell death, and iv) the new information on the pathogenesis of Alzheimer's, Huntington's and Parkinson's diseases, highlighting the role of Ca2+ and mitochondria.
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关键词：
Mitochondria Calcium Neurodegenerative disease Alzheimer's disease Parkinson's disease Huntington's disease
DOI：
10.1016/j.bbabio.2009.02.021
被引量：
年份：
2009
Elsevier
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Elsevier
国家科技图书文献中心
(权威机构)
万方医学
掌桥科研
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