摘要：

The authors have employed the multiparameter approach on several large case series. In these reported case series the classification of cases is based entirely on the morphologic features and the designated cytologic type compared with the results of the multiparameter studies. These studies confirm the T and B cell types of the Lukes-Collins classification and the rarity of histiocytic lymphoma. The present report includes the results on 425 cases of non-Hodgkin lymphomas and related leukemias as well as review the immunologic background of our functional approach. It also considers briefly the new clinical-immunologic cytologic entities that are emerging from the redefinition of the malignant lymphomas.

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