Leishmaniases in Bolivia: Comprehensive Review and Current Status

摘要:

The leishmaniases are protozoan, zoonotic diseases transmitted<sup> </sup>to human and other mammal hosts by the bite of phlebotomine<sup> </sup>sandflies. Bolivia has the highest incidence of cutaneous leishmaniasis<sup> </sup>(CL) in Latin America (LA), with 33 cases per 100,000 population<sup> </sup>reported in 2006. CL is endemic in seven of the country's<sup> </sup>nine administrative departments. Visceral leishmaniasis (VL)<sup> </sup>is comparatively rare and is restricted to one single focus.<sup> </sup>Most CL cases are caused by Leishmania (Viannia) braziliensis<sup> </sup>(85% cases); VL is caused by L. (L.) infantum. Seven sandfly<sup> </sup>species are incriminated as vectors and Leishmania infections<sup> </sup>have been detected in several non-human mammal hosts. Transmission<sup> </sup>is associated with forest-related activities, but recently,<sup> </sup>cases of autochthonous, urban transmission were reported. Because<sup> </sup>most cases are caused by L. (V.) braziliensis, Bolivia reports<sup> </sup>the greatest ratio (i.e., up to 20% of all cases) of mucosal<sup> </sup>leishmaniasis to localized CL cases in LA. Per national guidelines,<sup> </sup>both CL and VL cases are microscopically diagnosed and treated<sup> </sup>with pentavalent antimony.<sup> </sup>

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年份:

2009

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