The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.
摘要：
Cell proliferation requires nutrients, energy, and biosynthetic activity to duplicate all macromolecular components during each passage through the cell cycle. It is therefore not surprising that metabolic activities in proliferating cells are fundamentally different from those in nonproliferating cells. This review examines the idea that several core fluxes, including aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, form a stereotyped platform supporting proliferation of diverse cell types. We also consider regulation of these fluxes by cellular mediators of signal transduction and gene expression, including the phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR system, hypoxia-inducible factor 1 (HIF-1), and Myc, during physiologic cell proliferation and tumorigenesis.
展开
关键词：
Animals Humans Neoplasms Signal Transduction Cell Proliferation Models, Biological Hypoxia-Inducible Factor 1 Phosphatidylinositol 3-Kinases
DOI：
10.1016/j.cmet.2007.10.002
被引量：
年份：
2008
Taylor & Francis
Elsevier
Elsevier
(全网免费下载)
万方医学
掌桥科研
查看更多
dx.doi.org
NCBI
BioMed Central
Europe PMC
NCBI
Cell Press
(全网免费下载)
Cell Press
Oxford Univ Press
ResearchGate
(全网免费下载)
ResearchGate
mcponline.org
deepdyve.com
cghjournal.org
scienceopen.com
molbiolcell.org
gastrojournal.org
infona.pl
jlr.org
fundacion-barcelo.com.ar
(全网免费下载)
advances.sciencemag.org
fundacion-barcelo.com.ar
(全网免费下载)
utsouthwestern.influuent.utsystem.edu
jacionline.org
mct.aacrjournals.org
ashjournal.com
pubfacts.com
mendeley.com
msb.embopress.org
rstb.royalsocietypublishing.org
science-open.com
onAcademic
neoplasia.com
core.ac.uk
(全网免费下载)
pubget.com
www.socolar.com
yadda.icm.edu.pl
(全网免费下载)
Elsevier
(全网免费下载)
Cell Press
(全网免费下载)
ResearchGate
(全网免费下载)
core.ac.uk
(全网免费下载)
fundacion-barcelo.com.ar
(全网免费下载)
yadda.icm.edu.pl
(全网免费下载)
fundacion-barcelo.com.ar
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
