摘要：

Zr-terephthalate MOFs UiO-66 and UiO-66-NH2 are found to be highly diastereoselective catalysts for the synthesis of pyrano[3,2-c]quinolines through an inverse electron-demand azaDiels-Alder [4+2] cycloaddition of an aryl imine (formed in situ from aniline and an aldehyde) and 3,4-dihydro-2H-pyran in one pot, affording the corresponding trans isomer in 90-95% diastereomeric excess. The solids are stable under the reaction conditions and can be reused at least three times without significant loss of activity or diastereoselectivity.

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