Posttransplantation Lymphoproliferative Disorder Mimicking a Nonspecific Lymphocytic Pleural Effusion in a Bone Marrow Transplant Recipient

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作者：

E Lechapt-Zalcman，C Rieux，C Cordonnier，D Desvaux

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摘要：

BACKGROUND: Serous effusions are rare complications of bone marrow transplantation (BMT) and result mainly from infections or tumor relapse. CASE: We report a case of posttransplantation lymphoproliferative disorder (PTLD) revealed by cytodiagnostic examination of serious effusions in a BMT recipient. The effusion was initially considered reactive, but morphologic, immunocytologic and molecular studies subsequently revealed PTLD. CONCLUSION: This case demonstrates the importance of cytologic examination of effusions in BMT or organ recipients. Since most PTLDs are Epstein-Barr virus (EBV)-associated B-cell lymphoproliferative disorders and T cells predominate in reactive effusions, appropriate initial immunostaining, including CD3, CD79a and EBV latent membrane protein, should aid in their early detection. [References: 20]

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关键词：

bone marrow transplantation lymphoproliferative disorders pleural effusion

DOI：

10.1159/000330985

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年份：

1999