Division of labor in polycomb group repression.
摘要：
The epigenetic maintenance of gene expression patterns is essential for developing and maintaining the diverse types of cell that cooperate to form the larger organism. Recent data suggest that proteins of the Polycomb group (PcG) use a combination of posttranslational modifications and structural changes to the underlying chromatin structure to maintain silenced epigenetic states. We are now beginning to understand the mechanisms by which the PcG proteins are able to silence genes and to maintain this silencing over many cell divisions.
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关键词：
HISTONE METHYLTRANSFERASE ACTIVITY IMPRINTED X-INACTIVATION H3 LYSINE-27 METHYLATION DROSOPHILA-ZESTE PROTEIN GROUP-COMPLEXES GENE-EXPRESSION DNA-BINDING GAGA FACTOR TRANSCRIPTIONAL REPRESSION SELF-ASSOCIATION
DOI：
10.1016/j.tibs.2004.07.007
被引量：
年份：
2004
Elsevier
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