摘要：

The present invention relates to chimeric proteins with cell-targeting specificity and apoptosis-inducing activities. In particular, the invention is illustrated by examples of chimeric proteins of a cell-targeting moiety and an apoptosis-inducing moiety, such as cytochrome C, a caspase, e.g., Caspase3, DNA fragmentation factor (DFF40), a fragment of an apoptotic protein of the Bcl-2 family, such as Bik, Bax and Bak, etc,. The chimeric proteins specifically target cells expressing a binding site for the target protein, and induce cell-specific apoptosis.

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