PIN1 peptidyl - prolyl isomerase polypeptide, their crystal structure, and use for the drug design of those
申请(专利)号:
JP20040519118
申请日期:
2003-06-27
公开/公告号:
JP2005532061A
公开/公告日期:
2005-10-27
申请(专利权)人:
ファイザー インコーポレイテッド
摘要:
PIN1 peptidyl - it contains a prolyl isomerase domain, describes a polypeptide which does not include the PIN1 WW domain. In addition, PIN1 PPI-ase: I have described the crystal structure of these polypeptides, including the crystal structure of the ligand complex. Structure coordinate data derived from these crystals, PIN1 peptidyl - a three-dimensional outline of the prolyl isomerase substrate-binding site - useful PIN1 peptidyl to the design and discovery of the drug on the design and identification of modulators of the prolyl isomerase activity It is intended to provide.
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