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The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer.

来自 dx.doi.org

阅读量：

1266

作者：

E Middleton，C Kandaswami，TC Theoharides

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摘要：

Flavonoids are nearly ubiquitous in plants and are recognized as the pigments responsible for the colors of leaves, especially in autumn. They are rich in seeds, citrus fruits, olive oil, tea, and red wine. They are low molecular weight compounds composed of a three-ring structure with various substitutions. This basic structure is shared by tocopherols (vitamin E). Flavonoids can be subdivided according to the presence of an oxy group at position 4, a double bond between carbon atoms 2 and 3, or a hydroxyl group in position 3 of the C (middle) ring. These characteristics appear to also be required for best activity, especially antioxidant and antiproliferative, in the systems studied. The particular hydroxylation pattern of the B ring of the flavonoles increases their activities, especially in inhibition of mast cell secretion. Certain plants and spices containing flavonoids have been used for thousands of years in traditional Eastern medicine. In spite of the voluminous literature available, however, Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional. Suggestions are made where such possibilities may be worth pursuing.

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关键词：

Immune System Animals Humans Blood Platelets Mast Cells Coronary Disease Heart Diseases Inflammation Ascorbic Acid Flavonoids

DOI：

doi:10.1006/phrs.2000.0734

被引量：

7428

年份：

2000

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来源期刊

Pharmacological Reviews
2000 Dec;

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2012
被引量：629

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