Potentiation of immune responses with liposomal adjuvants

阅读量:

30

申请(专利)号:

US19900485388

申请日期:

1990-02-26

公开/公告号:

US6090406A

公开/公告日期:

2000-07-18

申请(专利权)人:

THE LIPOSOME COMPANY, INC.

发明人:

MC PopescuAL WeinerMS RecineAS JanoffL EstisLD KeyesCR Alving

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被引量:

373

摘要:

A high integrity liposome comprising at least one stabile lipid and at least one peptide-like therapeutic agent associated with said liposome, adapted for parenteral administration to an animal, including a human, and method according to manufacture and use. Immunizing dosage forms comprising a liposome and an immunogen, wherein said liposome and immunogen are present in an immunization dose. Additionally, a dosage form, including such form particularly adapted to producing an immune response, comprising a salt according to an organic acid derivative of a sterol and an immunogen wherein said organic acid derivative of a sterol and immunogen are present in an immunization dose, and method according to use is disclosed. Further, a dosage form, including such form particularly adapted to producing an immune response, comprising dimyristoylphosphatidylcholine (DMPC)/cholesterol liposomes, optionally in an aluminum hydroxide gel, and an immunogen wherein said DMPC/cholesterol and immunogen are present in an immunization dose, and method according to use.

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2011
被引量:74

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