Abnormal cell lineages in mutants of the nematode Caenorhabditis elegans

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摘要：

The phenotypes of cell lineage mutants of the nematode Caenorhabditis elegans are described. The mutants, which define 14 genes, differ in the breadth and nature of their phenotypic defects. Mutants in four genes display very general abnormalities in cell division and may be altered either in cellular maintenance and growth or in the mechanics of cell division and/or DNA replication. Mutants in two genes are specifically defective in the movements and divisions of certain hypodermal nuclei. Mutants in six genes are affected in vulva development in the hermaphrodite and, in some cases, in homologous aspects of sexual maturation in the male; some of these mutants are blocked in vulval cell divisions, whereas others undergo extra divisions to generate multiple ectopic pseudovulvae; these genes appear to specify which of two alternative fates is assumed by a set of six cells involved in vulva development. Mutants in two genes produce reiterations in certain cell lineages, i.e., specific cells generate descendants similar to themselves in both their division patterns and the fates of their progeny; these genes may control primary determinative events that occur during the course of a cell lineage.

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关键词：

Binocular disparity invariant object recognition spatial-frequency analysis optical flow Wigner distribution

DOI：

10.1016/0012-1606(81)90427-9

被引量：

650

年份：

1981