Therapeutic approaches to Alzheimer's disease

Alzheimer's disease is an age-related progressive neurodegenerative disorder with an enormous unmet medical need. It is the most common form of dementia af...

K Hans-Wolfgang，S Matthias，K Johannes，... - 《Brain A Journal of Neurology》

Oxidative stress in Alzheimer's disease

Oxidative balance is emerging as an important issue in understanding the pathogenesis of Alzheimer's disease. Examination of Alzheimer's disease brain has ...

MA Smith，CA Rottkamp，A Nunomura，... - BBA - Molecular Basis of Disease

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders.

Advances in our understanding of the mechanisms of tau-mediated neurodegeneration in Alzheimer's disease (AD) and related tauopathies, which are characteri...

Carlo，Ballatore，V M-Y，... - 《Nature Reviews Neuroscience》

The molecular pathology of Alzheimer's disease

Alzheimer's disease (AD) is the most common cause of dementia in elderly people, and the fourth most common cause of death in developed nations. Clinically...

D Yates，DM Mcloughlin - 《Psychiatry-interpersonal & Biological Processes》

The role of TRPM channels in cell death

Transient receptor potential (TRP) channels of the melastatin-like family (TRPM) play critical roles in mediating cellular responses to a wide range of phy...

S Mcnulty，E Fonfria - 《Pflügers Archiv》

Magnesium in acute and chronic brain injury: an update.

While brain free magnesium levels have been shown to decline in a number of acute and chronic brain pathologies, the mechanisms of such decline and the pot...

R Vink，NL Cook，CVD Heuvel - 《Magnesium Research》

Mechanistic study of TRPM2-Ca2+-CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition

Reactive oxygen species (ROS) have been commonly accepted as inducers of autophagy, and autophagy in turn is activated to relieve oxidative stress. Yet, wh...

Q Wang，W Guo，B Hao，... - 《Autophagy》